EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

doi:10.1016/S0140-6736(89)91013-1

The Lancet

Volume 334, Issue 8670, 28 October 1989, Pages 997-1000

https://doi.org/10.1016/S0140-6736(89)91013-1 Get rights and content

Abstract

N^G monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy volunteers to study the role of NO in the control of forearm blood flow. L-NMMA caused a 50% fall in basal blood flow and attenuated the dilator response to infused acetylcholine but not that to glyceryl trinitrate. These results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man. Impairment of production of NO might account for the abnormalities in vascular reactivity that characterise a wide variety of disease states.

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EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

Abstract

Biochem Biophys Res Commun

Biochem Biophys Res Commun

Lancet

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Nature

Paradoxical vasoconstriction produced by acetylcholine m atherosclerotic coronary arteries

N Engl J Med

The loss of endothelium-dependent vascular relaxation in hypertension

Hypertension

Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor

Nature

Vascular endothelial cells synthesise nitric oxide from L-arginine

Nature

Role of endothelium-derived nitric oxide m the regulation of blood pressure

Proc Natl Acad Sci USA

The measurement of volume changes m human limbs

J Physiol

Modulation of the vasodepressor actions of acetylcholine, bradykinin, substance P and endothelin in the rat by a specific inhibitor of nitric oxide formation

Br J Pharmacol