Elsevier

The Lancet

Volume 334, Issue 8656, 22 July 1989, Pages 205-206
The Lancet

Diagnosis
SPUTUM INDUCTION FOR DIAGNOSIS OF PNEUMOCYSTIS CARINII PNEUMONIA

https://doi.org/10.1016/S0140-6736(89)90382-6Get rights and content

Abstract

51 patients infected with the human immunodeficiency virus (HIV) and with suspected Pneumocystis carinii pneumonia underwent sputum induction. Sputum specimens from 18 patients were positive for P carinii and patients were treated appropriately. 25 of the 33 patients with negative specimens underwent bronchoscopy and bronchoalveolar lavage within 4 days of sputum induction, only 1 of whom had evidence of Pneumocystis infection. For diagnosis of Pneumocystis carinii pneumonia, sputum induction according to a strict protocol had a sensitivity of 94·7% and a negative predictive value of 96%, compared with bronchoalveolar lavage.

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