Letters to the EditorMELATONIN/CORTISOL RATIO IN DEPRESSION
References (4)
- et al.
A simplified radioimmunoassay for melatonin and its application to biological fluids: Preliminary observations on the half life of plasma melatonin in man
Clin Chim Acta
(1978) - et al.
Neuroendocrine regulation in affective disorders
Cited by (113)
Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment
2022, Behavioural Brain ResearchCitation Excerpt :Still, it has recently been shown that the phase angle between cortisol acrophase and dim-light melatonin onset (20 pg/ml) appears to differentiate healthy from depression, but additional studies with larger sample sizes deserve intensive investigation [59]. Consistent with that, plenty of evidence considered the melatonin/cortisol ratio as a significant criterion for distinguishing different types of depression and assessing the severity of depression [60]. In a double-blind study design, it was demonstrated that CRH, which is thought to be involved in HPA abnormalities in depressed patients, inhibited dramatically melatonin secretion [61].
An historical view of the pineal gland and mental disorders
2011, Journal of Clinical NeuroscienceCitation Excerpt :In this way, Anton-Tay et al.75 suggested that this hormone might have an antidepressive effect, an argument reinforced by the observation of the euphoric effect caused by melatonin following administration to healthy volunteers. Continuing with this research line, at the end of the 1970s, Wetterberg et al.76 found a reduction in the plasma levels of melatonin in depressive subjects and a specific reduction of night-time values in patients with suicidal ideas, as well as normalization following spontaneous recovery or after antidepressant treatment, while Mendlewicz et al.77 described the rhythms for the synthesis of melatonin in depressive patients, highlighting the absence of the nocturnal peak in melatonin characteristic of normal subjects (Fig. 4). The group of Lennart Wetterberg et al. in Stockholm has proposed a hypothesis known as “low melatonin syndrome”, whereby a low secretion of melatonin would constitute a biological marker for greater susceptibility to suffer a depressive disorder.76
Melatonin affects the immobility time of rats in the forced swim test: The role of serotonin neurotransmission
2006, European NeuropsychopharmacologySerum melatonin and urinary 6-sulfatoxymelatonin in major depression
2004, PsychoneuroendocrinologyDepression and endogenous melatonin in postmenopausal women
2002, Journal of Affective DisordersMelatonin in psychiatric disorders: A review on the melatonin involvement in psychiatry
2001, Frontiers in Neuroendocrinology