CommentHuntington's disease out of the closet?
References (5)
Stigma, history, and Huntington's disease
Lancet
(2010)The epidemiology of Huntington's disease
Cited by (48)
Regulatory roles of the miR-200 family in neurodegenerative diseases
2019, Biomedicine and PharmacotherapyCitation Excerpt :The miR-200 family may participate in the pathogenesis of ALS through regulating many molecular circuits, which needs to be clarified to develop new therapeutic strategies. Huntington's disease (HD) is a genetic neurodegenerative disease, which affects approximately 6–7 per 100 000 people in the United Kingdom, but the true prevalence may be greater [84]. HD is caused by abnormal expanded Cytosine-Adenine-Guanine (CAG) repeats in the gene encoding protein Huntingtin (HTT) [85].
Huntington disease
2018, Handbook of Clinical NeurologyCitation Excerpt :The prevalence of HD varies across the globe. In Western and European populations, it has typically been quoted at around 4–10/100,000 people (Harper, 2002); however, a more recent study from the United Kingdom suggests it may be closer to 12.3/100,000 population (Rawlins, 2010; Evans et al., 2013). This makes it among the more common of the inherited neurologic diseases.
Dysregulation of system x<inf>c</inf><sup>-</sup> expression induced by mutant huntingtin in a striatal neuronal cell line and in R6/2 mice
2014, Neurochemistry InternationalCitation Excerpt :Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by an expansion of the CAG region in exon 1 of the huntingtin gene (htt) (The Huntington’s Disease Collaborative Research Group, 1993) affecting approximately 10 in 100,000 people (Rawlins, 2010).
Epigenetic modifications in trinucleotide repeat diseases
2013, Trends in Molecular MedicineCitation Excerpt :It is clear, however, that differential DNA methylation in regions flanking the TNR in DMPK, particularly in different tissues, is likely to be an important contributing factor to the variable clinical outcome of this disease. HD is the most common TNR-associated disease with a prevalence estimated at 12.4 per 100 000 [89,90]. HD is an autosomal dominant, progressive neurodegenerative disorder which can result in involuntary movements (chorea), dementia, and, in some affected individuals, psychiatric symptoms.
Heuristic Approach to Curate Disease Taxonomy Beyond Nosology-Based Standards
2023, Communications in Computer and Information ScienceHealthcare resource utilization and costs in individuals with Huntington’s disease by disease stage in a US population
2022, Journal of Medical Economics