CorrespondenceTesofensine and weight loss
References (3)
- et al.
Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial
Lancet
(2008)
There are more references available in the full text version of this article.
Cited by (2)
Central nervous system stimulants and drugs that suppress appetite
2011, Side Effects of Drugs AnnualCitation Excerpt :After 24 weeks, tesofensine 0.25 and 0.5 mg/day had no significant effect on systolic and diastolic blood pressures compared with placebo, but heart rate increased by 7.4/minute. However, there is a reduction in blood pressure of 3–5 mmHg systolic and 2–3 mmHg diastolic with weight losses of 4–5 kg, and increases of 1 mmHg in systolic pressure and 2–3 mmHg in diastolic pressure among participants taking tesofensine 0.5 mg compared with controls seem to suggest that tesofensine can increase blood pressure [119r]. Drug development in the field of weight reduction has regularly faced pharmacovigilance hurdles, because anorexigenic drugs affect various neurotransmitter systems and can lead to serious adverse effects.
Copyright © 2009 Elsevier Ltd. All rights reserved.