CorrespondenceδF508 heterozygosity and asthma
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Cited by (20)
Risk of asthma in heterozygous carriers for cystic fibrosis: A meta-analysis
2016, Journal of Cystic FibrosisCitation Excerpt :However, it is still unclear whether heterozygous carriers of CF are susceptible to asthma. Some studies have reported a positive association [3–7], while other studies have shown no association [8–17]. About 1 in 30 Caucasians, 1 in 65 Africans and 1 in 90 Asians carries a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [18].
Fifteen-year follow-up of pulmonary function in individuals heterozygous for the cystic fibrosis phenylalanine-508 deletion
2001, Journal of Allergy and Clinical ImmunologyFrequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis
2001, ChestCitation Excerpt :Another possibility is that CFTR mutations contribute to enhancedimmunologic and inflammatory responses to A fumigatus. Anepidemiologic survey35 found a higher prevalence of positive skin-prick tests to A fumigatus in ΔF508 carriersthan in noncarriers, although there was no difference in the prevalenceof asthma. In addition, there is emerging evidence that CF isassociated with altered production of cytokines in the airways, including interferon-γ, interleukin (IL)-8, and IL-10, which couldresult in inappropriately regulated inflammatory and immunologicprocesses.3839
The Association between CFTR Gene Mutation Heterozygosity and Asthma Development: A Systematic Review
2023, Journal of Clinical Medicine
Data available from the authors or from The Lancet.