Elsevier

The Lancet

Volume 352, Issue 9132, 19 September 1998, Page 985
The Lancet

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δF508 heterozygosity and asthma

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Cited by (20)

  • Risk of asthma in heterozygous carriers for cystic fibrosis: A meta-analysis

    2016, Journal of Cystic Fibrosis
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    However, it is still unclear whether heterozygous carriers of CF are susceptible to asthma. Some studies have reported a positive association [3–7], while other studies have shown no association [8–17]. About 1 in 30 Caucasians, 1 in 65 Africans and 1 in 90 Asians carries a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [18].

  • Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis

    2001, Chest
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    Another possibility is that CFTR mutations contribute to enhancedimmunologic and inflammatory responses to A fumigatus. Anepidemiologic survey35 found a higher prevalence of positive skin-prick tests to A fumigatus in ΔF508 carriersthan in noncarriers, although there was no difference in the prevalenceof asthma. In addition, there is emerging evidence that CF isassociated with altered production of cytokines in the airways, including interferon-γ, interleukin (IL)-8, and IL-10, which couldresult in inappropriately regulated inflammatory and immunologicprocesses.3839

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