Elsevier

The Lancet

Volume 363, Issue 9419, 1 May 2004, Pages 1411-1412
The Lancet

Commentary
Immunomodulatory functions of mesenchymal stem cells

https://doi.org/10.1016/S0140-6736(04)16134-5Get rights and content

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    However, since mesenchymal stem cells can differentiate and regenerate damage tissues, they were administered along with rifampicin and were able to restore the elevated kidney bio-indicators to their normal range in both the parents and the offspring compared with the control group, as shown in Figs. 3–5 above. This may be due to the immune-modulatory properties of MSCs in the repair process of damage organs as reported [21,24,28,34,35,39]. Furthermore, the mechanism of action of bone marrow mesenchymal stem cells can be attributed to their competency to move and engraft to the site of damage, regardless of tissue type, thus making BMMSCs a good source of therapeutic material.

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    As for allogeneic cells, immunogenicity is the first obstacle. Reports showed that MSC is a low immunogenic cell type [48]. Even though, ethic and cell source still should be considered.

  • Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into cholinergic-like neurons in vitro

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    Thus, it has been postulated that WJ-MSCs could be used for cell transplantation therapy and represent a more eligible source of MSCs [8]. It has been increasingly recognized that WJ-MSCs may differentiate into several cell lineages in all three germ layers such as chondrocytes [24], osteoblasts [24], adipocytes [9], cardiomyocytes [24], adenocytes [14], hepatocytes [5], gliocytes [27] and neurocytes [10,24,25]. However, the capacity of WJ-MSCs to differentiate into cholinergic-like neurons remains undetermined.

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