CommentaryImmunomodulatory functions of mesenchymal stem cells
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Cited by (76)
Modulatory and regenerative potential of transplanted bone marrow-derived mesenchymal stem cells on rifampicin-induced kidney toxicity
2018, Regenerative TherapyCitation Excerpt :However, since mesenchymal stem cells can differentiate and regenerate damage tissues, they were administered along with rifampicin and were able to restore the elevated kidney bio-indicators to their normal range in both the parents and the offspring compared with the control group, as shown in Figs. 3–5 above. This may be due to the immune-modulatory properties of MSCs in the repair process of damage organs as reported [21,24,28,34,35,39]. Furthermore, the mechanism of action of bone marrow mesenchymal stem cells can be attributed to their competency to move and engraft to the site of damage, regardless of tissue type, thus making BMMSCs a good source of therapeutic material.
An electrospun fiber reinforced scaffold promotes total meniscus regeneration in rabbit meniscectomy model
2018, Acta BiomaterialiaCitation Excerpt :As for allogeneic cells, immunogenicity is the first obstacle. Reports showed that MSC is a low immunogenic cell type [48]. Even though, ethic and cell source still should be considered.
Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into cholinergic-like neurons in vitro
2013, Neuroscience LettersCitation Excerpt :Thus, it has been postulated that WJ-MSCs could be used for cell transplantation therapy and represent a more eligible source of MSCs [8]. It has been increasingly recognized that WJ-MSCs may differentiate into several cell lineages in all three germ layers such as chondrocytes [24], osteoblasts [24], adipocytes [9], cardiomyocytes [24], adenocytes [14], hepatocytes [5], gliocytes [27] and neurocytes [10,24,25]. However, the capacity of WJ-MSCs to differentiate into cholinergic-like neurons remains undetermined.
Stem Cells and Regenerative Strategies for Wound Healing: Therapeutic and Clinical Implications
2024, Current Pharmacology Reports