Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat1

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In adult rats, the first meal on restoring access to food following the complete absorption of an intragastric carbohydrate load is smaller than the meal following a nonnutritive load. The weanling rat does not show this postabsorptively induced satiation. The effect does not appear until above a body weight of about 200 g. Subcutaneous injection of a moderate dose of insulin (0.2 units/kg) at the time of glucose intubation results in postabsorptive satiety appearing in the immature rat. The inhibitor of insulin secretion, D-mannoheptulose, injected shortly before glucose intubation, considerably reduces the satiety effect in the 300 g rat. It is suggested that an abundant secretion of insulin during absorption is necessary to establish the parenteral satiety signal operative under these conditions.

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1

Work carried out at the School of Biological Sciences, University of Sussex, with support from a Grant from the Medical Research Council, United Kingdom, 1969–1972. We thank Mrs. D. Tucknott for technical assistance.

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