[8] Monoclonal antibodies specific for the native, disease-associated isoform of the prion protein
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Cited by (39)
Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex
2020, Schizophrenia ResearchNovel assay with fluorescence-labelled PrP peptides for differentiating L-type atypical and classical BSEs, and scrapie
2012, FEBS LettersCitation Excerpt :Furthermore, prions consist of multiple types that are classified by incubation periods and lesion profiles in inbred mice [2]. Some prions may also differ in their PrPSc properties, e.g. different electrophoretic mobilities [3], relative glycoform ratios [4], N-terminal ends of proteinase K (PK) digested PrPSc [5], immunoreactivities against conformational-specific antibodies [6,7], and stabilities against chaotropes [8]. These differences suggest that prion identity is encoded by the conformation of PrPSc, but little research has been done to confirm this.
Characterisation of new monoclonal antibodies reacting with prions from both human and animal brain tissues
2008, Journal of Immunological MethodsIdentification of an epitope on the recombinant bovine PrP that is able to elicit a prominent immune response in wild-type mice
2007, Immunology LettersCitation Excerpt :Instead, mice lacking a functional Prnp gene (Prnp0/0 mice) were used predominantly [13] and there are numerous reports of the successful production of mAbs after immunization with recombinant PrPs [14–18]. The well-known mAb 6H4 was generated by immunizing Prnp0/0 mice with a reduced form of recombinant bovine PrP (recBoPrP) [14,15]. In another approach, the immune system has been circumvented by the immunization of wild-type mice with chemically modified recombinant PrP proteins.