Original contributionMyoepithelial differentiation in high-grade invasive ductal carcinomas with large central acellular zones☆
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2012, Annals of OncologyCitation Excerpt :In their study, rim enhancement pattern—which is a feature highly predictive of malignancy—was the most common enhancement pattern, and was found in 76% of triple-negative carcinomas [10]. At least 90% of BBCs/TNBCs are invasive ductal cancers with a high mitotic index, central necrotic zones and pushing borders [15, 16] (see Figures 2 and 3). The MR appearances reflect this aggressive biology.
"Targeting" triple-negative breast cancer: The lessons learned from BRCA1-associated breast cancers
2011, Seminars in OncologyCitation Excerpt :The majority of TNBCs are of high histologic grade, with more than 90% of triple-negative (TN) tumors reported to be of invasive ductal histology.5,6 TN tumors also have been reported to have a high mitotic index, high Ki67 expression, central necrosis, pushing margins, and dense lymphocytic infiltrate.7-10 While TN refers to tumors that lack expression of ER, PR, and HER2 on the basis of IHC analysis, basal-like breast cancer (BLBC) is a classification based on gene expression profiling.11,12
Triple-Negative/Basal-Like Breast Carcinomas
2022, A Comprehensive Guide to Core Needle Biopsies of the Breast, Second Edition
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Supported in part by a grant-in-aid from the Ministry of Health and Welfare, Japan.