Elsevier

Human Pathology

Volume 29, Issue 3, March 1998, Pages 207-210
Human Pathology

Editorial
Expanding the clinicopathologic spectrum of herpes simplex encephalitis

https://doi.org/10.1016/S0046-8177(98)90036-3Get rights and content

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    • Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised

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      During the second week, inflammation and necrosis appeared predominantly in medial temporal and olfactory stria/inferior frontal lobes, cingulate gyri, and occasionally pontine nuclei. By the third week, there was extensive necrosis, inflammation, and gliosis with scant HSV-1.17,27 In contrast, in immunocompromised hosts, there was a conspicuous lack of inflammation, necrosis, and hemorrhage on histopathology, with persistence of abundant viral antigens.7,20,24,28

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