Abnormal neutrophils in acute myeloid leukemia and myelodysplastic syndromea
References (30)
- et al.
Abnormalities in granule formation in acute myelogenous leukemia
Blood
(1977) - et al.
Azurophil and specific granules of blood neutrophils in chronic myelogenous leukemia: an ultrastructural and cytochemical analysis
Blood
(1974) - et al.
APAAP labelling of blood and bone marrow samples for phenotyping leukaemia
Lancet
(1986) Abnormal neutrophils in acute myelogenous leukemia: identification of subpopulations based on analysis of azurophil and specific granules
Blood Cells
(1975)Myeloperoxidase-deficient polymorphonuclear leucocytes: longitudinal study during the preremission and the remission phase of acute myeloid leukaem comparison to neutrophil alkaline phosphatase (NAP) activity
Blut
(1986)Myeloperoxidase-deficient polymorphonuclear leucocytes (VII): incidence in untreated myeloprolifcrative disorders
Scand J Haematol
(1986)- et al.
Myeloperoxidase-deficient polymorphonuclear leucocytes (I): incidence in untreated myeloid leukaemia, lymphoid leukaemia and normal humans
Scand J Haematol
(1983) - et al.
Myeloperoxidase-deficient polymorphonuclear leucocytes (II): longitudinal study in acute myeloid leukaemia untreated, in remission, and in relapse
Scand J Haematol
(1983) - et al.
Myeloperoxidase-deficient polymorphonuclear leucocytes (IV): relation to FAB-classification in acute myeloid leukaemia
Scand J Haematol
(1985) - et al.
Myeloperoxidase-deficient neutrophils in acute myeloid leukaemia
Scand J Haematol
(1972)
The French-American-British (FAB) Co-operative Group: proposals for the classification of the myclodysplastic syndromes
Br J Haematol
Cytochemical and ultrastructural studies of aberrant granules in the neutrophils of two patients with myeloperoxidase deficiency during a preleukem state
Blood Cells
Prognostic significance of functional defects of granulocytes in myeloproliferative disease
Oncology
Quantitative cytochemistry of blood neutrophils in acute myeloid leukaemia
Br J Haematol
Studies on abnormal polymorphonuclear neutrophils in acute myelogenous leukemia: clinical significance and changes after chemotherapy
Am J Hematol
Cited by (34)
Managing Myelodysplastic Syndrome and the Nurse Practitioner's Role
2019, Journal for Nurse PractitionersCitation Excerpt :Dysplastic red blood cells may display ring sideroblasts in the presence of excess iron or may appear misshapen such as teardrop or spur cells.14 Dysplastic nucleated white blood cells may be abnormally large, display abnormal granularity, and/or have abnormal nuclear lobation.15 Platelets may also display abnormal morphology, resulting in platelets that are too large or too small.
The evolving clinical scenario of myelodysplastic syndrome: The need for a complete and up to date upfront diagnostic assessment
2010, European Journal of Internal MedicineCitation Excerpt :Red cell hypoplasia may rarely occur [32]. Neutrophil shows dysplastic features such as hypo-granularity and acquired Pelger-huet anomaly (hypo-segmentated or bi-lobated polymorphonuclear leucocytes) and ring-shaped nuclei [31,33–35]. Giant platelets or megakaryocyte fragments may be present in peripheral blood film.
Lipoid pneumonia with chronic myelomonocytic leukemia
2009, Pathology Research and PracticeThe myelodysplastic syndromes: Diagnosis and treatment
2006, Mayo Clinic ProceedingsCitation Excerpt :Acquired functional and morphologic abnormalities of blood cells are common in MDS and frequently exacerbate the consequences of cytopenias. These defects include acquired α-thalassemia with hemoglobin H in erythrocytes (also, β-thalassemia, membrane disruption,65 and enzymopathies66 can be observed rarely),58 pseudo-Pelger-Huët67 and hypogranular neutrophil morphology with impaired chemotaxis and microbicidal activity,68,69 and dysfunctional platelet activation and aggregation70–72 with storage pool deficiency73,74 or low surface glycoprotein expression.75 The presence of unexplained monocytosis, peripheral blood cytopenia(s), erythrocyte macrocytosis (even if the hemoglobin level is normal), or cellular atypia and dysplasia on a peripheral blood test should prompt further evaluation.
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Supported by a grant from the Leukaemia Research Fund. Dr.Gatter is a Wellcome Senior Research Fellow in Clinical Science.
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From the Department of Pathology, State University of New York Health Science Center, Syracus, New York
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From the Nuffield Department of Pathology, University of Oxford, John Radcliffe Hospital, Oxford, England.