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doi:10.1016/S0040-4039(98)01597-4 
Copyright © 1998 Published by Elsevier Science Ltd.
The first asymmetric carbonylation of 1-(6′-methoxy-2′-naphthyl)ethanol to the methyl ester of (S)-naproxen
Received 17 January 1998;
accepted 20 April 1998.
Available online 2 November 1998.
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Abstract
1-(6′-Methoxy-2′-naphthyl)ethanol is asymmetrically carbonylated to the methyl ester of (S)-naproxen in a PdCl2---CuCl2-DDPPI (DDPPI: 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-L-iditol) catalytic system with a chemical yield of 90% and an optical yield of 81% e.e.. The reaction was carried out in ethyl methyl ketone under 100°C and 8 MPa of CO for 24–48h.
Graphical Abstract
1-(6′-methoxy-2′-naphthyl)ethanol asymmetrically carbonylates to methyl ester of (S)-naproxen in a PdCl2---CuCl2---DDPPI (DDPPI: 1,4:3,6-dianhydro-2,5-dideoxy-2,5-bis(diphenylphosphino)-l-iditol) catalytic system.
