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doi:10.1016/S0040-4039(98)00988-5 
Copyright © 1998 Published by Elsevier Science Ltd.
A highly active palladium catalyst system for the arylation of anilines
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Joseph P. Sadighi, Michele C. Harris and Stephen L. Buchwald*
Received 23 March 1998;
Abstract
The chelating ligand bis[2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides. The bisphosphine is easily prepared in large quantity and at low cost by a known procedure. The catalyst system is effective in coupling reactions involving a variety of substrates, including electron-poor anilines or electron-rich aryl bromides. In addition, it tolerates a high degree of steric congestion at both the aniline and the aryl bromide.
Graphical Abstract
The known, readily accessible chelating ligand bis[2-(diphenylphosphino)phenyl] ether (DPEphos), in combination with palladium acetate, forms a highly active catalyst system for the coupling of anilines with aryl bromides.
