Organomanganese (II) reagents XX: Manganese mediated Barbier and Reformatsky like reactions an efficient route to homoallylic alcohols and β-acetoxyesters

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Abstract

Allylic halides and α-bromoesters react with manganese metal in ethyl acetate; THF can also be used as solvent if a catalytic amount of zinc chloride is added to the reaction mixture. When the reaction is performed in the presence of various aldehydes or ketones, excellent yields of 1,2-addition products are obtained in preparative conditions.

Allylic halides and α-bromoesters react with manganese metal in ethyl acetate; THF can also be used as solvent if a catalytic amount of zinc chloride is added to the reaction mixture. When the reaction is performed in the presence of various aldehydes or ketones, excellent yields of 1,2-addition products are obtained in preparative conditions.

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References (5)

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For part XIX see : G. Cahiez and B. Laboue, Tetrahedron Lett., preceding letter.

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