Two novel diketopiperazines isolated from the fungus Tolypocladium sp.
Two novel diketopiperazines, Sch 54794 and Sch 54796, have been isolated from a fungal fermentation and identified by spectral methods.
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2023, Arabian Journal of ChemistryMolecular Genetics of Secondary Chemistry in Metarhizium Fungi
2016, Advances in GeneticsCitation Excerpt :This NRPS is nested in a more conserved gene cluster found around M-NRPS27/M-PKS4 couple (Fig. 1-Y). Examples of fungal diketopiperazines among entomopathogenic species include SCH 54794, SCH 54796, and SCH 56396 from a Tolypocladium sp. (Chu et al., 1993; Chu, Truumees, Mierzwa, Patel, & Puar, 1997), bisdethiodi (methylthio)-1-demethylhyalodendrin and 1-demethylhyalodendrin tetrasulfide and the dimer vertihemiptellide from T. hemipterigena (Isaka, Palasarn, Rachtawee, Vimuttipong, & Kongsaeree, 2005; Nilanonta et al., 2003), and terezine D from Paecilomyces cinnamomeus and its teleomorph, T. luteorostrata (Isaka, Palasarn, Kocharin, & Hywel-Jones, 2007). Inasmuch as depsipeptides incorporating hydroxy acids by ester linkages can be biosynthesized by canonical NRPSs, it seems possible that the combination of an α-hydroxy acid and an amino acid to form a diketomorpholine ring as in metacytofilin (see Section 2.2.2) could be produced by genes that are predicted to produce diketopiperazines.
Diversity of Secondary Metabolites from Fungi of the Ascomycete Genus Tolypocladium
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