Elsevier

Tetrahedron

Volume 44, Issue 11, 1988, Pages 3379-3390
Tetrahedron

Inverse Electron Demand Diels-Alder Reactions of 2,4,6-Tris(ethoxycarbonyl)-l,3,5-triazine and 2,4,6-Tris(methylthio)-1,3,5-triazine: Pyrimidine Introduction

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Abstract

A full investigation of the scope of the participation of 2,4,6-tris(ethoxycarbonyl)-1, 3,5-triazine (1a) and 2.4.6-tris(methylthio)-1,3,5-triazine (1b) in inverse electron demand Diels-Alder reactions suitable for the preparation of functionalized 5,6-disubstituted pyrimidines is detailed. The use of the resulting [4 + 2] cycloadducts as immediate precursors to the parent 4,5-disubstltuted pyrimldines is described.

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