Inhibition of steroid nucleus degradation in mycobacterial transformations
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Cited by (36)
Application of microbial 3-ketosteroid Δ<sup>1</sup>-dehydrogenases in biotechnology
2021, Biotechnology AdvancesCitation Excerpt :Similarly, iron-chelating agents have been used to inhibit the enzyme in several different microorganisms, and to increase the yield of ADD (Wix et al., 1968). These chelating agents included 2,2’-dipyridyl, 2,2,2"-terpyridyl, 1,10-phenanthroline and derivatives, 8-hydroxyquinoline and derivatives, and cupferron, among others (Arima et al., 1968; Wix et al., 1968). However, they may be toxic and may adversely impact cell growth, and, therefore, they are generally introduced during the stationary phase of the microbial fermentation (Ahmad et al., 1992; Malaviya and Gomes, 2008).
Androstenedione production by biotransformation of phytosterols
2008, Bioresource TechnologyCitation Excerpt :When 3-ketosteroid-1(2)-dehydrogenase alone is active, it inserts a double bond between the C1 and C2 position and ADD is formed; when 9α-hydroxylase alone is active, a hydroxyl group is inserted at the C9 position and 9α-hydroxy-4-androstene-3,17-dione is formed. When both enzymes are inactive, AD is the primary compound synthesized (Wix et al., 1967; Kieslich, 1985). In the presence of enzyme inhibitors, cholesterol, β-sitosterol, campesterol, stigmasterol and their mixtures can be effectively converted to C19, C22 or C27 steroids.
Steroid 17β-reduction by microorganisms - A review
2005, Process Biochemistry
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Deceased in 1965.