A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants☆
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2019, Mutation Research - Genetic Toxicology and Environmental MutagenesisAssociation between methylenetetrahydrofolate reductase C677T polymorphism and epilepsy susceptibility: A meta-analysis
2014, SeizureCitation Excerpt :Based on the search criteria, a total of 81 potentially relevant publications were identified, and three of them were selected from the reference lists of the identified articles. After careful selection, 10 eligible studies5,18,19,30–36 were finally included in this meta-analysis. All control samples from included studies were in HWE.
Homocysteine, folic acid and vitamin B12 levels in serum of epileptic children
2012, Egyptian Journal of Medical Human GeneticsCitation Excerpt :AEDs may interfere with both absorption and metabolism of folate. It has also been suggested that AED-mediated decrease in plasma folate concentrations may in part represent a drug–gene interaction [30,14]. It is worth noting that in the study done in 2005 by Huemer et al. [11] intervention with folic acid resulted in significantly higher folate and lower tHcy concentrations at weeks 6 and 12 compared with patients receiving placebo [13].
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Supported by the research fund of Samsung Biomedical Research Institute (C-98-029) and Samsung Medical Center.