Results of Radiotherapy for Chemodectomas
Section snippets
MATERIAL AND METHODS
Between 1974 and 1988, 10 patients were assessed in the Division of Radiation Oncology at the Mayo Clinic because of unresectable, locally recurrent, or partially resected chemodectomas (Table 1). Included in this series were seven women and three men whose ages ranged from 36 to 68 years (median age, 54.5 years).
Symptoms included tinnitus (in eight patients), hoarseness (in six), loss of hearing (in six), dysphagia (in four), pain (in three), and alteration of mental status (in one). Many
RESULTS
The results were analyzed for both subjective and objective (measurable) responses to therapy (Table 1). In all nine assessable patients, the symptoms diminished after radiotherapy.
Objective responses were based on data from physical examination and radiographic studies. Of the nine assessable patients, four achieved a complete objective response, and one achieved a partial objective response. The other four patients had stable abnormalities at follow-up examinations. All nine assessable
DISCUSSION
Chemodectomas are rare, slow-growing tumors of the paraganglia. These tumors occur primarily in the carotid bodies or temporal bones. Treatment recommendations include operation only, radiotherapy only, or a combination of surgical treatment and radiotherapy.
Radiotherapy resulted in diminished symptoms and objective control of the tumor (no evidence of progression) in all our assessable patients. The Mayo Clinic experience with treatment of chemodectomas of the temporal bones before 1965 was
CONCLUSION
The results in the current series and those reported in the literature support the efficacy of radiotherapy in achieving local control of chemodectomas. The long-term toxicity is modest and can be minimized with use of careful technique. We believe that radiotherapy is a reasonable alternative to surgical treatment of these lesions. Radiotherapy should be considered the treatment of choice in those patients with unresectable, recurrent, and subtotally resected tumors. Irradiation should also be
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Radiothérapie et paragangliomes jugulaires
2014, Annales Francaises d'Oto-Rhino-Laryngologie et de Pathologie Cervico-FacialeTreatment of head and neck paragangliomas with external beam radiation therapy
2014, International Journal of Radiation Oncology Biology PhysicsCitation Excerpt :Radiation therapy is therefore an alternative treatment of choice for these localizations. For jugular paragangliomas, our results are similar to those of a recent review of the literature (1989-2010), in which the local control rate was 93% (Table 4) (3, 4, 8-12, 14-19). Previously, Pryzant et al (15) estimated local control at 89% with radiation therapy for 373 patients in a series lasting from 1964 to 1989.
Radiotherapy for glomus jugulare paraganglioma
2014, European Annals of Otorhinolaryngology, Head and Neck DiseasesCitation Excerpt :This definition is now widely accepted and the published results all appear to be concordant, regardless of the technique used. All studies published since the 1970s have reported tumour control rates close to 90% [12,16–25]. In his doctorate thesis, Dupin reported a 5-year local control rate of 97% and a 10-year local control rate of 94%, i.e. better results than those obtained with surgery [24].
Stereotactic radiosurgery as the primary treatment for new and recurrent paragangliomas: Is open surgical resection still the treatment of choice?
2012, World NeurosurgeryCitation Excerpt :In 1995, Kida et al. (71) were the first to recommend that the radiosurgical ablation of PGs was a viable alternative to open resection. Since then, numerous other series have reported the results of using SRS to manage PGs (32, 38, 57, 68, 85, 122). Tumors treated with SRS may not decrease in size, even when treatment is successful, complicating radiologic assessment of the outcome (33, 38, 41, 81).