Continuum model of fibroblast-driven wound contraction: Inflammation-mediation*
References (67)
- et al.
Fibroblast chemotaxis
Collagen Rel. Res.
(1985) Cutaneous tissue repair: Basic biological considerations
J. Am. Acad. Dermatol.
(1985)- et al.
Measurement of mechanical forces generated by skin fibroblasts embedded in a three-dimensional collagen gel
J. Invest. Dermatol.
(1991) - et al.
Cell motion, contractile networks and the physics of interpenetrating flow
Biophys. J.
(1986) - et al.
Studies on vascular smooth muscle cells and dermal fibroblasts in collagen matrices. Effects of heparin
Exp. Cell Res.
(1986) - et al.
Distribution of fibronectin during wound healing in vivo
J. Invest. Dermatol.
(1981) - et al.
Regulation of cell adhesion receptors by transforming growth factor-β: concomitant regulation of integrins that share a β1 subunit
J. Biol. Chem.
(1989) - et al.
Mechanical stress and cellular metabolism in living soft tissue composites
Biomaterials
(1990) - et al.
Fetal response to injury in the rabbit
J. Pediatr. Surg.
(1987) - et al.
Two dimensional mechanical properties of rabbit skin—II. Experimental results
J. Biomech.
(1974)
Stress relaxation of contracted collagen gels: disruption of actin filament bundles, release of cell surface fibronectin, and down-regulation of DNA and protein synthesis
Exp. Cell Res.
The mechanism of wound contraction and epithelialization
Clinics Plastic Surg.
Mechanochemical models for generating biological pattern and form in development
Physics Lett.
Oxygen and wound healing
Clinics Plastic Surg.
The Mechanical Basis of Morphogenesis. I. Epithelial folding and invagination
Dev. Biol.
Wound closure: an analysis of the relative contributions of contraction and epithelialization
J. Surg. Res.
Connective tissue morphogenesis by fibroblast traction
Dev. Biol.
A model for the role of hyaluronic acid and fibrin in the early events during the inflammatory response and wound healing
J. theor. Biol.
Contact inhibition in tissue culture
In Vitro
Hypoxia and endotoxin induce macrophage-mediated suppression of fibroblast proliferation
J. Trauma
The reconstitution of living skin
J. Invest. Dermatol.
The influence of extracellular matrix on gene expression : is structure the message?
J. Cell Sci.
Healing and contraction of experimental full thickness wounds in the human
Br. J. Surg.
Overview and general considerations of wound repair
A set of library routines for solving parabolic equations in one space variable
ACM Trans. Math. Sofw.
Characterising a kinesis response: time averaged measures of cell speed and directional persistence
Agents and Actions
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing
N. Engl. J. Med.
The role of connective tissue matrix in wound healing
Prog. Clin. Biol. Res.
Biomechanics
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
Experientia
Chemoattractants in fibrotic disorders
Traction, and its relations to contraction in tissue cell migration
Tissue culture cells on deformable substrata: biomechanical implications
J. Biomechan. Eng.
Cited by (0)
- *
It was also in part supported (J.D.M.) by grant DMS-900339 from the National Science Foundation.
- †
Myofibroblasts are mesenchymal cells, perhaps deriving from dedifferentiated fibroblasts in the adjacent dermis, which share the ECM biosynthetic properties of dermal fibroblasts and the extensive actin filament motility system of smooth muscle cells. It is because of the latter property and their common observation in granulation tissue that they were originally proposed to be the cell type underlying wound contraction [Gabbiani et al. (1971); references to the original papers for all of the relevant findings stated here can be found in the review by Skalli & Gabbiani (1988)]. Subsequently, the myofibroblast concentration was reported to be relatively uniform throughout the wound granulation tissue during the time-course of wound contraction and positively correlated with the rate of contraction (McGrath & Hundahl, 1982).