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Neutrophil chemotaxis and transcriptomics in term and preterm neonates
2017, Translational ResearchCitation Excerpt :Sepsis remains a prominent cause of neonatal mortality especially among preterm neonates. Previous studies have demonstrated that neonatal neutrophils specifically have qualitative impairments of adherence, chemotaxis, phagocytosis, neutrophil respiratory burst activity, and release of extracellular traps, compared to adults.14-21 However, these findings have been largely based on experiments that utilized cord blood from term neonates and required detailed neutrophil isolation.
Normal and Abnormal Neutrophil Physiology in the Newborn
2017, Fetal and Neonatal Physiology, 2-Volume SetInnate immune cell recruitment in the fetus and neonate
2011, Journal of Reproductive ImmunologyCitation Excerpt :The comparison of newborns delivered vaginally vs. newborns delivered by caesarean section before onset of labor demonstrated that labor-induced stress leads to the upregulation of Mac-1 and the IL-8 receptor CXCR1 on neonatal neutrophils (Gessler and Dahinden, 2003) and enhances neutrophil adhesion (Kinoshita et al., 1991) and chemotaxis (Yektaei-Karin et al., 2007). In contrast, during sepsis the chemotactic response of fetal and neonatal cells deteriorates (Merry et al., 1996). Since multiple of these factors may be present when examining the function of fetal and neonatal immune cells, it is difficult and challenging to distinguish whether observed differences are due to extrinsic influences or intrinsic developmental effects.
Role of innate host defenses in susceptibility to early-onset neonatal sepsis
2010, Clinics in PerinatologyCitation Excerpt :The process of PMN recruitment and extravasation to sites of inflammation is less efficient in neonates compared with older age groups and likely contributes to their increased susceptibility to early infection. Specifically, PMNs from preterm and term neonates exhibit reduced basal chemotaxis and random migration123 that is exacerbated in septic and postoperative newborns.124 Impaired signaling downstream of chemokine-receptor binding may be partially responsible for this finding.125
The innate immunity in preterm-newborn
2010, Pediatria PolskaThe immunocompromised pediatric patient and surgery
2008, Best Practice and Research: Clinical AnaesthesiologyCitation Excerpt :The chemotactic and adhesive capacities of PMNs are diminished in healthy neonates compared to adults. In septic neonates, these activities decline further while surgery and anesthesia did not appear to alter chemotaxis.7 Healthy term and preterm infants have normal phagocytic and microbicidal capacity.
Presented at the 42nd Annual International Congress of the British Association of Paediatric Surgeons, Sheffield, England, July 25–28, 1995.