This paper is devoted to study the existence of multiple positive solutions for the second order Dirichlet boundary value problem with impulse effects. The main results here is the generalization of Liu and Li [L. Liu, F.Y. Li, Multiple positive solution of nonlinear two-point boundary value problems, J. Math. Anal. Appl. 203 (1996) 610–625] for ordinary differential equations. Existence is established via the theory of fixed point index in cones.