Mast cell involvement in gastritis with or without Helicobacter pylori infection
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Determination of Biopsy Yield That Optimally Detects Eosinophilic Gastritis and/or Duodenitis in a Randomized Trial of Lirentelimab
2022, Clinical Gastroenterology and HepatologyPropolis: The future therapy against Helicobacter pylori-mediated gastrointestinal diseases
2018, Journal of Applied BiomedicineCitation Excerpt :Infiltrating mast cells release different proinflammatory cytokines and chemo-attractants, including PAF, IL-8, LTB4, TNFα, and GM-CSF (granulocyte-monocyte colony stimulating factor) and lead to neutrophil infiltration and inflammatory manifestations (Fig. 1). The mast cells, which are first-line defence of the host, may also contribute to the pathogenesis caused by H. pylori (Supajatura et al., 2002) and act as effector cells in this regard (Nakajima et al., 1997). Basophilic cells (bone-derived mast cells) produce different polyamines such as putrescine and spermine.
Mast cells in human digestive tube in normal and pathological conditions
2016, Immunology LettersCitation Excerpt :The gastrointestinal MCs perform their biological functions, releasing mediators, as amines (histamine, serotonin), cytokines, proteases, lipid mediators (leukotrienes, prostaglandins), and heparin [17–20]. In the stomach, MCs are distributed mainly in the upper third of the fundic glands portion and in the upper half of the pyloric glands [21]. The intestinal mucosa is coated with a monolayer of epithelial cells, including M cells, goblet cells, Paneth cells, and columnar epithelial cells and is exposed to various stimuli including food materials, commensal and pathogenic microorganisms.
Mast cell progenitors: Origin, development and migration to tissues
2015, Molecular ImmunologyCitation Excerpt :Mast cells in tissues are very long-lived (Padawer, 1974) and even after degranulation they re-granulate and live on (Walker, 1961; Kobayasi and Asboe-Hansen, 1969; Xiang et al., 2001). Many studies report on organ-specific increases in mast cell numbers in human disease (Patella et al., 1998; Terada and Matsunaga, 2000; Molin et al., 2002; Ribatti et al., 2000; O'Sullivan et al., 2000; Ammit et al., 1997; Brightling et al., 2002; Sugamata et al., 2005; Nakajima et al., 1997). The same pattern is also seen in disease models in mice (Dahlin et al., 2012; Yu et al., 2006; Hallgren et al., 2007; Kakizoe et al., 1999; Chang et al., 2011).
Mast cells: Emerging sentinel innate immune cells with diverse role in immunity
2010, Molecular Immunology