Selected SummariesProbiotic therapy with E. coli for ulcerative colitis: Take the good with the bad
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Comment
The above study has several significant flaws that limit the importance of the findings; specifically, this is a heterogeneous group of patients (mild to severe in illness severity), treated with various corticosteroid formulations in addition to the study medication. The mesalamine doses used were relatively low (1.2–2.4 g/day), and only a small number of patients were in remission at the end of the study, resulting in an underpowered equivalence study. Nonetheless, the hypothesis of the study
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Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota
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Probiotics and Prebiotics: Effects on Diarrhea
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2007, Gastroenterology Clinics of North AmericaCitation Excerpt :There was no significant difference in end points between the two groups; the authors concluded that E coli Nissle was as effective as mesalazine in maintaining remission of UC. Kruis and colleagues' initial study [78] was criticized for its short duration of follow-up; the second study with E coli Nissle may have been limited by the heterogeneity of the patient population, a relatively low mesalamine dose, and the high rate of relapse that limited the statistical power of the study [80]. In response to this, Kruis and colleagues [81] performed a much larger study to confirm the equivalence of E coli Nissle to mesalazine for maintenance of remission.
Bioecologic control of the gastrointestinal tract: The role of flora and supplemented probiotics and synbiotics
2005, Gastroenterology Clinics of North AmericaCitation Excerpt :Relapses during the study period occurred in 26 of 57 (67%) E coli Nissle–treated patients and 32 of 59 (73%) mesalamine-treated patients [89]. Subsequent reviewers have pointed out that the relapse rate in the mesalamine group was significantly higher than expected from the literature [91]. It also has been suggested that the study groups were heterogeneous with respect to severity of disease, and that the dose of mesalamine used in the study was lower than usually used.
Probiotics and inflammatory bowel disease
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