(R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats
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Therapeutic potential of targeting kynurenine pathway in neurodegenerative diseases
2023, European Journal of Medicinal ChemistryKynurenine emerges from the shadows – Current knowledge on its fate and function
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2021, Archives of Biochemistry and BiophysicsIn silico methods predict new blood-brain barrier permeable structure for the inhibition of kynurenine 3-monooxygenase
2020, Journal of Molecular Graphics and ModellingLPS-induced cortical kynurenic acid and neurogranin-NFAT signaling is associated with deficits in stimulus processing during Pavlovian conditioning
2017, Journal of NeuroimmunologyCitation Excerpt :These results suggest that inflammation may preferentially activate KYNA-Nrgn signaling in the mPFC. Moreover, our study is the first to show that pharmacological inhibition of KMO, which deviates kynurenine conversion toward KYNA (Erhardt et al., 2004; Justinova et al., 2013; Speciale et al., 1996), can effectively increase PKC-Nrgn phosphorylation in the mPFC. Supporting our findings, KMO null mice, which exhibit increased brain KYNA, also upregulates Nrgn mRNA expression (Erhardt et al., 2016).
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