Elsevier

L'Encéphale

Volume 38, Supplement 3, December 2012, Pages S110-S115
L'Encéphale

Interventions psychothérapeutiques et psychosociales et endophénotypes dans les troubles bipolairesPsychotherapeutic and psychosocial interventions and endophenotypes in bipolar disorders

https://doi.org/10.1016/S0013-7006(12)70088-XGet rights and content

Résumé

Maladies à déterminisme complexe, les troubles bipolaires, impliquent à la fois des facteurs de vulnérabilité environnementale et génétique. La caractérisation de ces vulnérabilités permettrait d’une part, une meilleure connaissance de leur étiologie et d’autre part, d’envisager le développement de nouvelles thérapeutiques, plus spécialisées, voire préventives. La recherche en psychiatrie génétique a permis de mettre en évidence des endophénotypes candidats associés aux troubles bipolaires. Ce sont des « traits » cliniques ou biologiques dits endogènes, plus simples, biologiquement plus élémentaires que les phénotypes cliniques et « liés » plus directement aux conséquences physiologiques des gènes et de leurs polymorphismes. Cibler certains d’entre eux avec des interventions psychothérapeutiques et psychosociales adaptées, pourrait réduire les conséquences liées à leur expression et ainsi avoir une action sur l’évolution de la maladie mais aussi préventive.

Summary

Diseases with complex determinism, bipolar disorders, involve at the same time environmental and genetic factors of vulnerability. The characterization of these vulnerabilities would allow a better knowledge of their etiology and envisage the development of therapeutics, more specialized, even preventive. The research in genetic psychiatry allowed to highlight endophenotype candidates associated to bipolar disorders. They are endogenous clinical or biological features, biologically more elementary than phenotypes and more directly bound to the physiological consequences of genes and their polymorphisms. Targeting some of them with specific psychotherapy and psychosocial interventions could reduce the consequences of their expression and so have an action on the course of the disease and also preventive.

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