A graph is called almost self-complementary if it is isomorphic to one of its almost complements , where X^c denotes the complement of X and a perfect matching (1-factor) in X^c. Almost self-complementary circulant graphs were first studied by Dobson and Šajna [Almost self-complementary circulant graphs, Discrete Math. 278 (2004) 23–44]. In this paper we investigate some of the properties and constructions of general almost self-complementary graphs. In particular, we give necessary and sufficient conditions on the order of an almost self-complementary regular graph, and construct infinite families of almost self-complementary regular graphs, almost self-complementary vertex-transitive graphs, and non-cyclically almost self-complementary circulant graphs.