The role of amines in the etiology of schizophrenia
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2007, Pharmacology and TherapeuticsThe Dopamine System and the Pathophysiology of Schizophrenia: A Basic Science Perspective
2007, International Review of NeurobiologyCitation Excerpt :Therefore, DA is now considered to be a neuromodulator. The reason for this substantial level of interest is due to its involvement in a number of neurological and psychiatric disorders including Parkinson's disease (Hornykiewicz, 1971; Lloyd and Hornykiewicz, 1970) and schizophrenia (Faurbye, 1968; Fischer, 1970). The loss of DA neurons in the nigrostriatal system has been shown to underlie the symptoms of Parkinson's disease (Hornykiewicz, 1971; Lloyd and Hornykiewicz, 1970), whereas excessive DA release has been suggested in the pathophysiology of schizophrenia.
Deuterium isotope effects on the enzymatic oxidative deamination of trace amines
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