Special articleRevisiting the essential role of oxygen in wound healing
Section snippets
Reactive derivatives of oxygen support healing: a new horizon
In the words of Thomas Hunt, a pioneer in the field of oxygen and wound healing, the search for the mechanisms by which O2 exerts its vital functions in wound healing has evolved another major step [3] making room for a new paradigm [4]. Recent discoveries have illuminated that not only phagocytes, but almost each and every cell in the wound microenvironment is fitted with a specialized enzyme to convert O2 to reactive oxygen species (ROS), including oxidizing species such as free radicals and H
Oxygen: beyond nutritional support
Angiogenesis is a critical early aspect of the wound healing response. While hypoxia can initiate neovascularization, it cannot sustain it. Supplemental O2 administration accelerates vessel growth [21]. It has been established that VEGF is a major long-term angiogenic stimulus at the wound site. O2 treatment induces VEGF mRNA levels in endothelial cells and macrophages [22], [23], [24] and increases VEGF protein expression in wounds in vivo [25]. Recently it has been shown that O2 may trigger
Oxygen as an antibiotic
Wound tissue pO2 levels are a major determinant of susceptibility to infection, and this has been shown both in experimental models and in human subjects. In a guinea pig model, the amount of skin loss seen after subcutaneous innoculation of bacteria was inversely proportional to wound oxygenation—hypoxic wounds were large, and the smallest wounds were seen in animals receiving supplemental O2. The efficacy of supplemental O2 in preventing skin loss was similar to antibiotic administration, and
Oxygen therapy: diagnostic, preventive and therapeutic
The availability of respired O2 to wound tissues depends upon vascular supply, vasomotor tone, arterial pO2, and the diffusion distance for molecular O2. Edema and necrotic debris both increase the diffusion distance for O2 to reach the wound, so debridement is an important step to diminish obstruction to wound oxygenation. Peripheral vasoconstriction can also significantly limit wound perfusion and oxygenation, so that little to no enhancement of wound pO2 levels are achieved despite breathing
Acknowledgements
Supported by GM27345 and DE013749 (seed) to CKS.
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2022, MaterialiaCitation Excerpt :The increase in cell viability was due to the reduction in H2O2 level as well as release of molecular oxygen which favor the cellular respiration. Wound healing is an energy demanding process so that oxygen is necessary for the release of required amount of energy for neovascularization, collagen synthesis and antimicrobial action [41]. It has been studied that the application of gaseous oxygen to wounds is much less effective than applying dissolved oxygen [42].