Cancer-associated human papillomavirus types are selectively increased in the cervix of women in the first trimester of pregnancy☆,☆☆,★,★★
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Patients and specimens
Patients were recruited from a municipal hospital obstetrics clinic and a gynecology clinic, as well as a sexually transmitted diseases (STD) clinic located about one block away from the other two clinics. Written informed consent was obtained from all patients in accordance with United States Department of Health and Human Services guidelines and a document approved by the Indiana University – Purdue University at Indianapolis Committee on Protection of Human Subjects. Pregnant patients were
Patient demographics and behavior characteristics
A total of 739 patients were enrolled (245 from the obstetrics clinic, 246 from the gynecology clinic, and 248 from the STD clinic). The demographic characteristics are shown in Table I. There were two potentially important differences among the patient groups. The mean age of the obstetrics clinic patients was significantly lower, 22.8 years compared with 28.2 years for the STD clinic patients and 29.2 years for the gynecology patients (p < 0.001). The STD clinic patients had significantly
COMMENT
There is a general impression among clinicians that overt HPV infections worsen during pregnancy and often improve in the postpartum period. Whereas such anecdotal observations and clinical experience have been widely accepted and even enshrined as facts in textbooks,16 there are few data from carefully controlled studies to support or refute this concept. An understanding of the interactions between the pregnant patient and infecting HPV is important for several reasons. There are concerns
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Cited by (66)
Human papilloma virus infection and miscarriage: is there an association?
2020, Taiwanese Journal of Obstetrics and GynecologyCitation Excerpt :Sexual behavior, including age of the first sexual intercourse and number of sexual partners, is the main risk factor for HPV infection [3,4]. Notably, HPV infection is more prevalent in pregnant than in age-matched non-pregnant women [5–7]. The prevalence of HPV infection also increases as pregnancy progresses [7–9].
Clinical outcome of high-grade cervical intraepithelial neoplasia during pregnancy: A 10-year experience
2019, European Journal of Obstetrics and Gynecology and Reproductive BiologyIdentification of novel human papillomavirus lineages and sublineages in HIV/HPV-coinfected pregnant women by next-generation sequencing
2016, VirologyCitation Excerpt :HPV clearance is lower during the first two trimesters of pregnancy, suggesting a compromised immune response (Hernandez-Giron et al., 2005; Nobbenhuis et al., 2002). Pregnancy is thus associated with increased HPV prevalence, and with more rapid progression to intraepithelial lesion (Armbruster-Moraes et al., 2000; Fife et al., 1996; Hernandez-Giron et al., 2005; Palle et al., 2000). HPV belongs to the Papillomaviridae family, and over 200 different HPV types have been described so far, based on their genetic distances, particularly in the L1 gene (http://www.hpvcenter.se/html/refclones.html).
Human papillomavirus infection and spontaneous abortion: A case-control study performed in Mexico
2013, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :It is important to study HPV detection in pregnancy, which represents a special immunological state that may be a risk factor for HPV infection [30]. Some studies have shown a higher frequency of HPV cervical infection in pregnant women compared to non-pregnant controls, possibly because of an effect of elevated estrogens which may affect the viral replication, or due to the altered immunity [31–34]. Nevertheless, in some settings the routine Pap smear is usually postponed for pregnant women, as mentioned in European guidelines [35].
Epidermodysplasia verruciformis-associated and genital-mucosal high-risk human papillomavirus DNA are prevalent in nevus sebaceus of Jadassohn
2008, Journal of the American Academy of DermatologyCitation Excerpt :Most high risk GM HPV infections occur in younger individuals and clear within several years.61-63 However, an increase in cervical HPV infection with high-risk GM HPV types has been observed during pregnancy64; this increase could potentially affect the conceptus. In this study, histologic and molecular evidence of HPV DNA infection was prevalent and persistent in NS as its absence was not associated with increasing age.
The prevalence and risk of human papillomavirus infection in pregnant women
2014, Epidemiology and Infection
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From the Departments of Medicine,a Microbiology and Immunology,b Pathology,c and Obstetrics and Gynecology,d Indiana University School of Medicine.
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Supported in part by grant AI 31494 (Project 4) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health.
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Reprint requests: Kenneth H. Fife, MD, PhD, Division of Infectious Diseases, 545 Barnhill Dr., Room 435, Indianapolis, IN 46202-5124.
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0002-9378/96 $5.00 + 0 6/1/69616