Effect of Antioxidant-Rich Foods on Plasma Ascorbic Acid, Cardiac Enzyme, and Lipid Peroxide Levels in Patients Hospitalized with Acute Myocardial Infarction
Section snippets
Subjects and Methods
Between July 1987 and June 1990, all patients admitted to the Medical Hospital and Research Center (Moradabad, India) within 24 hours of onset of suspected acute myocardial infarction were considered for this study. Details about patients and methods have been described elsewhere (12), (13). The diagnosis of acute myocardial infarction was made using a 12-lead electrocardiogram; the criteria (14) were symmetrical ST segment elevation 1 mm or more from baseline in limb leads, elevation of more
Results
(Table 1) shows that the percentages for number of men, subjects with hypertension, and other known risk factors were comparable for the two groups (12), (13). Smoking and alcohol intake were not different for the intervention and control groups (Table 1). Electrocardiographic sites of acute myocar-dial infarction and initial levels of cardiac enzymes were similar in both groups. The diagnoses of acute myocardial infarction, possible acute myocardial infarction, and unstable angina were also
Discussion
This study showed that increased consumption of antioxidant vitamin C increased the availability of plasma vitamin C by 75.5%, which may have resulted in the reduced lipid peroxide level (−16.5%) and a smaller increase inlactate dehydrogenase cardiac enzyme (65.0%) from initial levels. In contrast, changes were minor in the control group. Within the intervention group, subjects who consumed greater amounts of foods rich in ascorbic acid showed greater benefit at these levels: A rise in cardiac
Applications
The evidence of association between plasma ascorbate and acute myocardial infarction from this randomized, controlled intervention trial is sufficiently strong to suggest that foods rich in ascorbic acid, and possibly foods rich in other antioxidants such as vitamin E and beta carotene, should be provided to patients with acute myocardial infarction to quench free radical overproduction and prevent myocardial necrosis, complications, and mortality (12), (13), (31), (32), (33). Simultaneous
References (34)
- et al.
Risk of angina pectoris and plasma concentrations of vitamin A, C and E and carotene
Lancet.
(1991) - et al.
Studies of blood ascorbic acid levels in acute myocardial infarction
Clin Chim Acta.
(1975) - et al.
An Indian experiment with nutritional modulation in acute myocardial infarction
Am J Cardiol.
(1992) - et al.
Effect of tocopherol on hypoxic perfused and reoxygenated rabbit heart muscle
J Mol Cell Cardiol.
(1978) - et al.
Combination treatment with vitamin E and C in experimental myocardial infarction in pigs
Am Heart J.
(1989) - et al.
Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking
Athero-sclerosis.
(1990) - et al.
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
Lancet.
(1994) - et al.
Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross cultural epidemiology
Am J Clin Nutr.
(1991) - et al.
Does consumption of fruit and vegetables protect against strokes?
Lancet.
(1983) - et al.
Relationship of plasma level of vitamin C to mortality from ischemic heart disease
Ann N Y Acad Sci.
(1987)
Vitamin C intake and mortality among a sample of United States population
Epidemiology.
Vitamin C and cardiovascular risk factors
Am J Clin Nutr.
Effects of vitamin C on high density lipoprotein cholesterol and blood pressure
J Am Coll Nutr.
Leucocyte ascorbic acid and its relationship to coronary artery disease in man
Am J Clin Nutr.
Plasma levels of antioxidant vitamins and oxidative stress in patients with acute myocardial infarction
Acta Cardiol
Leucocyte ascorbic acid level after myocardial infarction
Br Heart J.
Randomized, controlled trial of cardioprotective diet in patients with recent acute myocardial infarctionresults of one year follow up
BMJ.
Cited by (45)
Functional food security for osteoporosis, carcinogenesis, atherosclerosis and brain degeneration
2018, The Role of Functional Food Security in Global HealthAssociation of dietary factors with severity of coronary artery disease
2016, Clinical Nutrition ESPENCitation Excerpt :In the present study, carbohydrate and fat (palmitic acid) intake were high; and protein and fiber intake were low in patients with TVD when compared to patients with SVD and DVD. A similar observation has been made by others [9,21,22]. A positive association between carbohydrate intake and progression of coronary atherosclerosis has been reported among postmenopausal women [21].
Reduction in saturated fat intake for cardiovascular disease
2020, Cochrane Database of Systematic ReviewsEffects of total fat intake on body fatness in adults
2020, Cochrane Database of Systematic ReviewsRole of oxidative stress in the pathogenesis and progression of coronary artery disease: An overview
2016, Chronocardiology and Cardiac Research