Structure
Volume 18, Issue 3, 10 March 2010, Pages 366-376
ArticleMode of Interaction between β2GPI and Lipoprotein Receptors Suggests Mutually Exclusive Binding of β2GPI to the Receptors and Anionic Phospholipids
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Highlights
► The structure of the β2GPI-DV/LA4 complex represents how β2GPI-DV binds LA modules ► LA modules interact with lysines 308, 317, and 282 of β2GPI-DV using residues at their Ca2+-coordination site ► A pair of LA modules efficiently binds β2GPI-DV dimerized by antibody ► β2GPI-DV cannot simultaneously bind to lipoprotein receptors and anionic phospholipids
PROTEINS
SIGNALING
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