Chemistry & Biology
Volume 17, Issue 10, 29 October 2010, Pages 1111-1121
ArticleDiscovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents
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Highlights
► Phenotypic screening cascade to classify small-molecule kinase inhibitor compounds ► Three types of kinase inhibitors: transcriptional, mitotic, and cell cycle ► Structure-based design of CDK9-selective kinase inhibitor compounds ► A drug-like CDK9 inhibitor compound with in vivo activity
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Present address: School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
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Present address: Veterinary School, University of Thessaly, Karditsa 43100, Greece
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Present address: South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
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