Chapter 1 - Introduction to Non-coding RNAs and High Throughput Sequencing

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Abstract

There are many kinds of non-coding RNAs (ncRNAs) in living cells. We briefly introduce six classes of ncRNAs that are covered and analyzed in the book: microRNA (miRNA), trans-acting small interfering RNA (tasiRNA) and phased small interfering RNA (phasiRNA), long non-coding RNA (lncRNA), lariat RNA, and circular RNA (circRNA). The functions of these ncRNAs and important issues when predicting them, and some online resources of miRNAs, lncRNAs, and circRNAs are also discussed. We also introduce some sequencing technologies for detecting and/or quantifying ncRNAs. Then we introduce some general computational tools that are used in the following parts of the book. Finally, we introduce several file formats for storage and analysis of nucleotide sequences and high throughput sequencing data, and several file formats for gene annotation.

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