Handbook of Epigenetics

Handbook of Epigenetics (Second edition)

The New Molecular and Medical Genetics
2017, Pages 167-190
Handbook of Epigenetics

Chapter 12 - Computational Epigenetics

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Abstract

Epigenetics has emerged as a rapidly growing field for studying the heritable alterations involved in the regulation of gene expression patterns that are not due to changes in DNA sequence. To which, the epigenetic mechanisms, such as DNA methylation and histone modifications, can modulate chromatin structure and gene regulation, during cellular development and differentiation in higher organisms. Recent advancements in high-throughput epigenetic profiling technologies, including bisulfite microarray, bisulfite sequencing, affinity enrichment, ChIP-on-chip, and ChIP sequencing, have generated vast amounts of epigenomic data. In turn, the developments of bioinformatics databases and software tools have thus contributed significantly to the substantial, and growing, interest in epigenetic research. This chapter reviews the key aspects and techniques of computational epigenetics. In particular, the major computational tools, databases, and strategies for epigenetics analysis of DNA methylation and histone modifications have been summarized.

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