Music is powerful. Its effects are so potent that it is used to increase desired behavior in retail settings, offices, gyms, and waiting rooms. Globally, people seek out and listen to music regularly, with research showing that an average listener engages with music for approximately 2.6 hours per day. It is such a desired commodity that those who produce well-loved music make millions of dollars in income and may give their entire professional lives over to its pursuit. This chapter summarizes research and thinking about the elements of music that give it so much power, the parts of the brain that respond to music, and emerging literature on brain connectivity related to music processing. Research on the effects of music on different disorders is reviewed. Finally, given what is known about music and the brain, we present ideas about how clinicians might utilize music to increase the power and efficacy of their interventions.