Injectable Cell Delivery Systems Based on Alginate Hydrogels for Regenerative Therapies

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Abstract

Due to their many attractive features, alginate hydrogels are amongst the most commonly used cell-entrapment matrices. They structurally recapitulate key features of native extracellular matrices and can be further bio-functionalized with cell-instructive moieties to specifically control cell behavior. The biomechanical properties of alginate hydrogels can be tuned to match those of different types of tissues, increasing their versatility. This review provides an overview on the general properties of alginate hydrogels and their application as injectable cell carriers for tissue regeneration, namely for therapeutic vascularization.

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This article is a reprint of S.J. Bidarra, A.L. Torres, C.C. Barrias, Injectable Cell Delivery Systems Based on Alginate Hydrogels for Regenerative Therapies, Reference Module in Materials Science and Materials Engineering, Elsevier, 2016.

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