Nuclear Architecture and Dynamics

Nuclear Architecture and Dynamics

Translational Epigenetics
2018, Pages 101-122
Nuclear Architecture and Dynamics

4 - Dynamic Chromatin Folding in the Cell

https://doi.org/10.1016/B978-0-12-803480-4.00004-1Get rights and content

Abstract

Although almost 40 years have passed since the nucleosome structure was discovered, how the nucleosome fiber is organized and behaves in live cells remains unclear and a fundamental question in cell biology. With the recent development of several novel and powerful strategies to address this question, our view of chromatin structure and dynamics is now shifting from a static crystal-like regular one to more dynamic liquid-like one. The dynamic nature of chromatin better explains various genome functions including RNA transcription, DNA replication, and DNA repair/recombination. In this chapter, based on available experimental evidence, we discuss our current knowledge of the dynamic folding of interphase chromatin and mitotic chromosomes.

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Cited by (4)

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