Chapter Seven - Diversity and Analysis of Bacterial Terpene Synthases
Section snippets
Terpenoid Metabolites from Bacterial Cultures
Tens of thousands of terpenoid metabolites, including monoterpenes, sesquiterpenes, and diterpenes, are present in both terrestrial and marine higher plants, in liverworts, and in fungi, with only a relatively minor fraction having been isolated from prokaryotes. These compounds act as antibiotics, hormones, flavor or odor constituents, and pigments. Some of them also possess other physiologically or commercially important properties, such as vitamins (A, D, E, K, and coenzyme Q) and antitumor
Bacterial Terpene Synthases
Several cyclic monoterpene, sesquiterpene, and diterpene hydrocarbons and alcohols are formed by variations of the common terpene cyclization mechanism that is initiated by enzyme-catalyzed ionization to form allylic cations from the universal acyclic precursors, geranyl diphosphate (GPP), farnesyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP) that are themselves synthesized by mechanistically related condensations of the 5-carbon building blocks dimethylallyl diphosphate (DMAPP) and
Properties of terpene synthases and database search procedures
Monoterpene, sesquiterpene, and diterpene synthases from plants and fungi have a strongly conserved amino acid sequence homology. Conversely, bacterial terpene synthases not only exhibit no significant overall sequence amino acid similarity to those from plants and fungi but also usually exhibit relatively low mutual sequence similarity to each other. Despite the very substantial differences in overall primary amino acid sequence, terpene synthases from plants, fungi, and bacteria typically
References (59)
- et al.
Cloning and characterization of Pfl_1841, a 2-methylenebornane synthase in Pseudomonas fluorescens PfO-1
Tetrahedron
(2011) Unearthing the roots of the terpenome
Current Opinion in Chemical Biology
(2008)Sesquiterpenoids from Actinomycetes: Cadin-4-en-1-ol
Phytochemistry
(1971)Volatile lactones from Streptomyces
Tetrahedron Letters
(1973)- et al.
Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin
The Journal of Biological Chemistry
(2002) - et al.
Genome mining in Streptomyces clavuligerus: Expression and biochemical characterization of two new cryptic sesquiterpene synthases
Chemistry and Biology
(2011) - et al.
Diterpene biosynthesis
- et al.
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus
The Journal of Biological Chemistry
(2011) - et al.
Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120
Journal of Bacteriology
(2008) - et al.
Sur l'odeur proper de la terre
Comptes Rendus de l'Académie des Sciences
(1891)