Familial parkinsonism: Our experience and review

doi:10.1016/1353-8020(95)00010-4

Parkinsonism & Related Disorders

Volume 1, Issue 1, July 1995, Pages 35-46

https://doi.org/10.1016/1353-8020(95)00010-4 Get rights and content

Abstract

There is substantial interest in the possible role of genetic factors in the etiology of idiopathic parkinsonism (IP) and parkinsonism-plus syndromes (PPS). We have longitudinally investigated eight large kindreds from North America. Five families demonstrated IP features, two families represented PPS and in one family, neither a diagnosis of IP or PPS could be established. A literature review supported our findings; only half of the published kindreds presented with a clinical picture typical of IP. Genetic DNA analysis is in progress on our kindreds and on many families in our literature review. The results may clarify the etiology and classification of IP and PPS.

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We identified approximately 570 indexed articles addressing familial parkinsonism. As expected, when we reviewed the selected articles, the majority of affected members in these families had predominant parkinsonism.12,14,15 If dementia was present in these families, it occurred in very few affected individuals.12
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Twenty-one families with three or more affected persons, consistent with autosomal dominant inheritance, were included in the study. A description of the genealogical and clinical methods used in the study of parkinsonian kindreds are detailed elsewhere (Denson and Wszolek 1995). Some of the families had been included into linkage previously, with no evidence for linkage to PARK1 and PARK3 in families A, D, M3, and M6. (
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ArticleFamilial parkinsonism: Our experience and review

Abstract

Electroenceph. Clin. Neurophysiol.

Parkinsonism Related Disord.

An Essay on the Shaking Palsy

Research on the genetics of Parkinson's disease

Is idiopathic parkinsonism the consequence of an event or a process?

Neurology

Pathogenesis of idiopathic parkinsonism

Eur. Neurol.

Parkinson's disease

Early onset Parkinson's disease: are juvenile and young-onset different?

Mov. Disord.

Positron emission tomography

Pathology of Parkinson's disease

Parkinsonism-plus syndromes

Mov. Disord.

Hereditary Lewy-body parkinsonism and evidence for a genetic etiology of Parkinson's disease

Brain Pathol.

Paralysis agitans. A clinical genetic study

Acta Psychiat. Neurol. Scand.

A family study of parkinsonism

Parkinson's disease in 65 pairs of twins and in a set of quadruplets

Neurology

Une forme familiale de paralysie agitante dans une souche des grisons

J. Genet Hum.

Report of familial cases of parkinsonism

JAMA

Hereditary mental depression and parkinsonism with taurine deficiency

Arch. Neurol.

Dominantly inherited apathy, central hypoventilation and Parkinson's syndrome: clinical biochemical, and neuropathologic studies of 2 new cases

Neurology

Familial fetal parkinsonism with alveolar hypoventilation and mental depression

Ann. Neurol.

New data on the genetics of Parkinson's disease

Can. J. Neurol. Sci.

Twin studies and the genetics of Parkinson's disease—a reappraisal

Mov. Disord.

A large kindred with autosomal dominant Parkinson's disease

Ann. Neurol.

Ein beitrag zu familiär gehäut auftretenden fallen von parkinsonismus

Nervenarzt.

A familial parkinson-dementia syndrome

Neurology

Familial Alzheimer's disease presenting as levodopa-responsive parkinsonism

Adv. Neurol.

Familial parkinsonism apathy, weight loss and central hypoventilation

Neurology

Clinical and neuropathological study of a familial case of juvenile parkinsonism

Jpn J. Psychiat. Neurol.

Enfermedad de Parkinson familiar

Neurologia

A parkinsonian kindred

Ital. J. Neurol. Sci.

Clinical features of autosomal recessive type juvenile parkinsonism and improvement of symptoms by smoking

Article
Familial parkinsonism: Our experience and review