ArticleFamilial parkinsonism: Our experience and review
References (62)
- et al.
Electrophysiologic findings in patients with rapidly progressive familial parkinsonism and dementia with pallido-ponto nigral degeneration
Electroenceph. Clin. Neurophysiol.
(1993) - et al.
Neurodegenerative overlap syndrome: clinical and pathological features of Parkinson's disease, motor neuron disease and Alzheimer's disease
Parkinsonism Related Disord.
(1995) An Essay on the Shaking Palsy
(1817)Research on the genetics of Parkinson's disease
Is idiopathic parkinsonism the consequence of an event or a process?
Neurology
(1994)- et al.
Pathogenesis of idiopathic parkinsonism
Eur. Neurol.
(1993) - et al.
Parkinson's disease
- et al.
Early onset Parkinson's disease: are juvenile and young-onset different?
Mov. Disord.
(1994) Positron emission tomography
- et al.
Pathology of Parkinson's disease
Parkinsonism-plus syndromes
Mov. Disord.
Hereditary Lewy-body parkinsonism and evidence for a genetic etiology of Parkinson's disease
Brain Pathol.
Paralysis agitans. A clinical genetic study
Acta Psychiat. Neurol. Scand.
A family study of parkinsonism
Parkinson's disease in 65 pairs of twins and in a set of quadruplets
Neurology
Une forme familiale de paralysie agitante dans une souche des grisons
J. Genet Hum.
Report of familial cases of parkinsonism
JAMA
Hereditary mental depression and parkinsonism with taurine deficiency
Arch. Neurol.
Dominantly inherited apathy, central hypoventilation and Parkinson's syndrome: clinical biochemical, and neuropathologic studies of 2 new cases
Neurology
Familial fetal parkinsonism with alveolar hypoventilation and mental depression
Ann. Neurol.
New data on the genetics of Parkinson's disease
Can. J. Neurol. Sci.
Twin studies and the genetics of Parkinson's disease—a reappraisal
Mov. Disord.
A large kindred with autosomal dominant Parkinson's disease
Ann. Neurol.
Ein beitrag zu familiär gehäut auftretenden fallen von parkinsonismus
Nervenarzt.
A familial parkinson-dementia syndrome
Neurology
Familial Alzheimer's disease presenting as levodopa-responsive parkinsonism
Adv. Neurol.
Familial parkinsonism apathy, weight loss and central hypoventilation
Neurology
Clinical and neuropathological study of a familial case of juvenile parkinsonism
Jpn J. Psychiat. Neurol.
Enfermedad de Parkinson familiar
Neurologia
A parkinsonian kindred
Ital. J. Neurol. Sci.
Clinical features of autosomal recessive type juvenile parkinsonism and improvement of symptoms by smoking
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Motor neurons loss in Parkinson Disease: An electrophysiological study (MUNE)
2021, Journal of Electromyography and KinesiologyCitation Excerpt :The classic pathological features of sporadic PD comprises of the degeneration of dopaminergic neurons in the substantia nigra and noradrenergic neurons in the locus coeruleus, although, there have been some reports of spinal cord lesions in patients with PD (Braak et al., 2009). Denson et al. (1995) and Vivacqua et al. (2012) also found enlarged axonal spheroids and Lewy bodies in the anterior horn of lumbar spinal cord. Although, the clinical overlap of motor neuron disease and PD is rare, there are cases with co-occurrence of pathological proven MND and PD (Chanson et al., 2010).
Identifying PD-causing genes and genetic susceptibility factors: Current approaches and future prospects
2010, Progress in Brain ResearchCitation Excerpt :Nevertheless, with the identification of these rare disease genes ‘neurogenetics’ has become part of the mainstream of neurology (Harbo et al., 2009). During the 1990s it became apparent that in some rare cases the much more common and typically sporadic neurologic disorders such as Parkinson’s disease (PD) (Denson and Wszolek, 1995), Alzheimer’s disease (AD) (Goate et al., 1991) or amyotrophic lateral sclerosis (Rosen et al., 1993) could also run in families following a Mendelian pattern of inheritance. In fact, it turned out that many of these monogenic variants of common diseases resemble the typical sporadic forms to a large degree both clinically (with the exception that age of onset is often younger in patients with inherited forms of these disorders) and pathologically, suggesting that the molecular pathways discovered through the relevant genes in hereditary forms may also be of importance in sporadic cases.
Genetic aspects of Parkinson's disease
2007, Handbook of Clinical NeurologyCitation Excerpt :The maximum multipoint lod score was 24.9 at D12S345. Then Zimprich et al. (2004b) did a linkage analysis on autosomal‐dominant families living in western societies, including families A (Denson & Wszolek, 1995) and D (Wszolek et al., 1995), reported previously. Both of these families reached significant linkage on their own, with a combined maximum multipoint lod score of 3.33.
Familial Occurrence of Dementia with Lewy Bodies
2004, American Journal of Geriatric PsychiatryCitation Excerpt :We identified approximately 570 indexed articles addressing familial parkinsonism. As expected, when we reviewed the selected articles, the majority of affected members in these families had predominant parkinsonism.12,14,15 If dementia was present in these families, it occurred in very few affected individuals.12
The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval
2004, American Journal of Human GeneticsCitation Excerpt :Twenty-one families with three or more affected persons, consistent with autosomal dominant inheritance, were included in the study. A description of the genealogical and clinical methods used in the study of parkinsonian kindreds are detailed elsewhere (Denson and Wszolek 1995). Some of the families had been included into linkage previously, with no evidence for linkage to PARK1 and PARK3 in families A, D, M3, and M6. (
PARK3, Ubiquitin Hydrolase-L1 and Other PD Loci
2003, Genetics of Movement Disorders