Chemistry & Biology
Volume 1, Issue 4, December 1994, Pages 191-195
Journal home page for Chemistry & Biology

Crosstalk
Cyclin-dependent kinases: regulators of the cell cycle and more

https://doi.org/10.1016/1074-5521(94)90009-4Get rights and content

Abstract

Cyclin-dependent kinases determine the timing of key events in the cell cycle, and may also regulate other important cellular functions. Although some of the effects of activating these kinases are clear, the mechanisms by which the effects are produced are not; several types of chemical probes that might be enlightening can be imagined.

References (12)

  • T.J. Mitchison

    Towards a pharmacological genetics

    Chemistry & Biology

    (1994)
  • A. Murray et al.

    The Cell Cycle: An Introduction

    (1993)
  • K.R. Schneider et al.

    Phosphate-regulated inactivation of the kinase PHO80-PHO85 by the Cdk inhibitor PHO81

    Science

    (1994)
  • A. Kaffman et al.

    Phosphorylation of the transcription factor PHO4 by a cyclin-Cdk complex, PHO80-PHO85

    Science

    (1994)
  • J. Lew et al.

    A brain-specific activator of cyclin-dependent kinase 5

    Nature

    (1994)
  • L.-H. Tsai et al.

    p35 is a neural-specific regulatory subunit of cyclin dependent kinase 5

    Nature

    (1994)
There are more references available in the full text version of this article.

Cited by (48)

  • The structure of the human cell cycle

    2022, Cell Systems
    Citation Excerpt :

    This canonical model, which has shaped our thinking for over 70 years, provides a useful framework for mapping key molecular events that govern the progression of a typical cell through the cell cycle. Advances in molecular biology, particularly in budding yeast, led to the identification of numerous cell cycle regulators (e.g., cyclins and cyclin-dependent kinases [CDKs]) controlling DNA replication, mitosis, and cell cycle arrest (Glotzer et al., 1991; Morgan, 2007; Murray, 1994). To accommodate these discoveries, more sophisticated models were proposed to describe the cell cycle’s overall behavior.

  • Development of CDK-targeted scoring functions for prediction of binding affinity

    2018, Biophysical Chemistry
    Citation Excerpt :

    Cyclin-dependent kinase (CDK) has been extensively examined as a target for drug development, mainly due to its role in controlling cell-cycle progression. In eukaryotic cells, CDK is responsible for checkpoints, which allow safely progress of cell cycle when this enzyme is active [1,2]. More recently, a CDK inhibitor has entered phase III of clinical trials for anticancer drug development, which further highlights the importance of CDK inhibition in the development of drugs against cancer [3].

  • The Cell Cycle

    2012, Physiology of the Gastrointestinal Tract, Two Volume Set
  • The Cell Cycle

    2012, Physiology of the Gastrointestinal Tract
  • Mitotic phosphorylation of Aki1 at Ser<sup>208</sup> by cyclin B1-Cdk1 complex

    2010, Biochemical and Biophysical Research Communications
    Citation Excerpt :

    This unidirectional cycle consists of four phases: mitosis (M phase), Gap1 (G1 phase), synthesis (S phase), and Gap2 (G2 phase). The cell cycle is primarily regulated by cyclin and cyclin-dependent kinase (Cdk) complexes [1–4]. Cyclin was originally identified as a protein that undergoes acute degradation during mitosis, and it was known for its fluctuating expression pattern, which is coincident with the cell cycle [5].

View all citing articles on Scopus
View full text