Chemistry & Biology
CrosstalkCyclin-dependent kinases: regulators of the cell cycle and more
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Cited by (48)
The structure of the human cell cycle
2022, Cell SystemsCitation Excerpt :This canonical model, which has shaped our thinking for over 70 years, provides a useful framework for mapping key molecular events that govern the progression of a typical cell through the cell cycle. Advances in molecular biology, particularly in budding yeast, led to the identification of numerous cell cycle regulators (e.g., cyclins and cyclin-dependent kinases [CDKs]) controlling DNA replication, mitosis, and cell cycle arrest (Glotzer et al., 1991; Morgan, 2007; Murray, 1994). To accommodate these discoveries, more sophisticated models were proposed to describe the cell cycle’s overall behavior.
Development of CDK-targeted scoring functions for prediction of binding affinity
2018, Biophysical ChemistryCitation Excerpt :Cyclin-dependent kinase (CDK) has been extensively examined as a target for drug development, mainly due to its role in controlling cell-cycle progression. In eukaryotic cells, CDK is responsible for checkpoints, which allow safely progress of cell cycle when this enzyme is active [1,2]. More recently, a CDK inhibitor has entered phase III of clinical trials for anticancer drug development, which further highlights the importance of CDK inhibition in the development of drugs against cancer [3].
The Cell Cycle
2012, Physiology of the Gastrointestinal Tract, Two Volume SetThe Cell Cycle
2012, Physiology of the Gastrointestinal TractMitotic phosphorylation of Aki1 at Ser<sup>208</sup> by cyclin B1-Cdk1 complex
2010, Biochemical and Biophysical Research CommunicationsCitation Excerpt :This unidirectional cycle consists of four phases: mitosis (M phase), Gap1 (G1 phase), synthesis (S phase), and Gap2 (G2 phase). The cell cycle is primarily regulated by cyclin and cyclin-dependent kinase (Cdk) complexes [1–4]. Cyclin was originally identified as a protein that undergoes acute degradation during mitosis, and it was known for its fluctuating expression pattern, which is coincident with the cell cycle [5].
Molecular modeling and dynamics simulation of human cyclin-dependent kinase 3 complexed with inhibitors
2009, Computers in Biology and Medicine