Original articleInhibition of nitric oxide synthesis causes systemic and pulmonary vasoconstriction in isoflurane-anesthetized dogs
References (43)
- et al.
Actions of isoflurane on myocardial perfusion in chronically instrumented dogs with poor, moderate, or well-developed coronary collaterals
J Cardiothorac Anesth
(1990) The effects of halothane and isoflurane on intracellular Ca++ regulation in cultured cells with characteristics of vascular smooth muscle
Cell Calcium
(1992)- et al.
Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: Implications for endotoxin shock
Biochem Biophys Res Commun
(1992) - et al.
Effects of infusion of l-Agnine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteries
Am J Cardiol
(1992) - et al.
Mechanisms of coronary vasospasm: Role of endothelium
J Mol Cell Cardiol
(1991) - et al.
Isoflurane induces coronary steal in a canine model of chronic coronary occlusion
Anesthesiology
(1987) Isoflurane causes more severe regional myocardial dysfunction than halothane in dogs with a critical coronary artery stenosis
Anesthesiology
(1988)- et al.
Isoflurane causes regional myocardial dysfunction in dogs with critical coronary artery stenoses
Anesthesiology
(1987) - et al.
Regional coronary hemodynamics during isoflurane-nitrous oxide anesthesia in patients with ischemic heart disease
Anesth Analg
(1983) - et al.
Isoflurane: A powerful coronary vasodilator in patients with coronary artery disease
Anesthesiology
(1983)
Myocardial metabolism and hemodynamic responses with isoflurane anesthesia for coronary arterial surgery
Anesth Analg
Global and regional myocardial blood flow and metabolism during equipotent halothane and isoflurane anesthesia in patients with coronary artery disease [comments]
Anesth Analg
No evidence for blood flow redistribution with isoflurane or halothane during acute coronary artery occlusion in fentanyl-anesthetized dogs
Anesthesiology
Effects of isoflurane and halothane on coronary vascular resistance and collateral myocardial blood flow: Their capacity to induce coronary steal
Anesthesiology
Isoflurane has a greater margin of safety than halothane in swine with and without major surgery or critical coronary stenosis
Anesth Analg
Hemodynamic dose-responses to halothane and isoflurane are different in swine with and without critical coronary artery stenosis
Anesth Analg
Halothane 1.5 MAC, isoflurane 1.5 MAC, and the contractile responses of coronary arteries obtained from human hearts
Anesth Analg
Intracoronary isoflurane causes marked vasodilation in canine hearts
Anesthesiology
Effects of halothane, enflurane, and isoflurane on coronary blood flow autoregulation and coronary vascular reserve in the canine heart
Anesthesiology
Isoflurane causes only minimal increases in coronary blood flow independent of oxygen demand
Anesthesiology
Steal-prone coronary circulation in chronically instrumented dogs: Isoflurane versus adenosine
Anesthesiology
Cited by (12)
Cerebrovascular changes in the rat brain in two models of ischemia
2014, PathophysiologyCitation Excerpt :Changes in the neurons, astrocytes, microglia and endothelial cells are primarily due to oxygen deprivation and energy shortage in the cells [26–29]. This in turn is signaled in the endothelium which then alters the smooth muscle layer to regulate blood flow to counter the oxygen shortage by increasing the circulatory volume in the cerebral region through vasodilatation induced by nitric oxide [27,30]. Findings from histology reveal that the physical properties of the arteries are intrinsically linked with the endothelia and smooth muscle thickness in the cerebral arteries [31].
Histochemical Alterations in One Lung Ventilation
2007, Journal of Surgical ResearchCitation Excerpt :The high variability of these nitrite levels and the fact that there was a significant change in the face of this high variability strengthens our finding that serum nitrite level were lowered over the experimental period. This high variability in serum nitrite levels may be a reflection of variable responses of individual pigs to isoflurane, where isoflurane has been reported to cause systemic pulmonary vasodilation by increasing levels of NO [19]. Inflammation associated with lung injury is characterized by neutrophil infiltration [20].
Inhaled nitric oxide administration during one-lung ventilation in patients undergoing thoracic surgery
2001, Journal of Cardiothoracic and Vascular AnesthesiaCitation Excerpt :Isoflurane and epidural analgesia can lead to decreased pulmonary vascular resistance. Isoflurane causes systemic and pulmonary vasodilation,24 and Moore et al25 showed that the systemic and pulmonary vasodilation caused by isoflurane are likely mediated by NO. Compared with intravenous agents, however, the increase in QS/QT related to isoflurane at <1 MAC was shown to be moderate in humans.26 Epidural block combined with general anesthesia has been shown to decrease pulmonary vascular resistance during surgery.27
Placebo-controlled study of inhaled nitric oxide to treat hypoxaemia during one-lung ventilation
1999, British Journal of AnaesthesiaInhaled nitric oxide (40 ppm) during one-lung ventilation, in the lateral decubitus position, does not decrease pulmonary vascular resistance or improve oxygenation in normal patients
1997, Journal of Cardiothoracic and Vascular AnesthesiaNitric oxide synthesis inhibition and right ventricular systolic function in swine
1996, Journal of Cardiothoracic and Vascular Anesthesia