Dual metalloprotease inhibitors.v. Utilization of bicyclic azepinonethiazolidines and azepinonetetrahydrothiazines in constrained peptidomimetics of mercaptoacyl dipeptides
A series of conformationally constrained dipeptide mimetics of Ala-Pro yielded potent dual-acting inhibitors of both angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP).
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