Regeneration in the adult mammalian CNS: guided by development
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2013, NeuroscienceCitation Excerpt :However, the relationship between the level of microglial activation and neuronal injury needs to be clarified in the future. Astrocytes are the major type of cells in the CNS (Korzus et al., 1997), and after CNS injury reactive astrocytes show increased motility and hyperplasia, secreting cytokines and neurotrophic factors (Aubert et al., 1995; Shen et al., 2010; Shang et al., 2011), and enhancing neurogenesis (Shang et al., 2011). There is also evidence that astrocytes play direct roles in synaptic transmission via the release of molecules, including glutamate, purines, GABA, and d-serine, that can alter neuronal excitability (Halassa et al., 2007; Perea et al., 2009).
Optical imaging of structural and functional synaptic plasticity in vivo
2013, European Journal of PharmacologyCitation Excerpt :Altogether, the cloning and characterization of growth and guidance proteins embodied a new trend in the thinking about neuronal plasticity: perhaps the growth-related molecules that are abundant during development continue to modulate plasticity in the adult brain, albeit in a more subtle way. Experiments in laboratory animals confirmed that plasticity and regeneration might represent replays of events that normally occur abundantly during development (Aubert et al., 1995). Clinical data too started to point towards quite robust types of plasticity within the adult CNS.