Effects of rare codon clusters on high-level expression of heterologous proteins in Escherichia coli
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Construction of 5-aminolevulinic acid synthase variants by cysteine-targeted mutation to release heme inhibition
2022, Journal of Bioscience and BioengineeringSlippy-Sloppy translation: a tale of programmed and induced-ribosomal frameshifting
2022, Trends in GeneticsCitation Excerpt :In addition to expression levels, tRNA availability compared with its respective anticodon can be a rate-limiting factor during translation. Indeed, because of a longer time required for the matching charged tRNA to be available, rare codons can affect protein production and quality [50,51]. In E. coli, for example, it was reported that rare codons for arginine induce stalling, leading to ribosomal frameshifting [52].
An Efficient Expression and Purification Protocol for SpCas9 Nuclease and Evaluation of Different Delivery Methods of Ribonucleoprotein
2024, International Journal of Molecular Sciences
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