Starting the cell cycle: what's the point?
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Cited by (105)
Nutrient Signaling, Stress Response, and Inter-organelle Communication Are Non-canonical Determinants of Cell Fate
2020, Cell ReportsCitation Excerpt :For budding yeast, the time of commitment to the mitotic cell cycle is denoted as “Start.” Once cells pass Start, they begin DNA replication, and the bud concomitantly emerges (Cross, 1995). Thus, we used yeast buds to determine the post-Start cells as in Jorgensen et al. (2002).
A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry
2015, Current BiologyCitation Excerpt :The G1 phase constitutes a critical period in which cells determine whether conditions are appropriate to begin dividing, and this decision is responsive to cues such as nutrient availability, cell size, and inhibitory signals. Ultimately, these cues affect the function of Cln1–Cln3, which then drive the CDK phosphorylation events that commit cells to division in a step known as “Start,” followed by the G1-to-S transition [6–8]. Key CDK substrates in this period are inhibitors of cell-cycle entry, such as Whi5, a repressor of G1/S transcription [9, 10], as well as Cdh1 and Sic1, which prevent the expression and activity of Clb cyclins, respectively [1].
Identification of the molecular mechanisms for cell-fate selection in budding yeast through mathematical modeling
2013, Biophysical JournalCitation Excerpt :This process must be restricted to the G1 phase, before the initiation of DNA replication. The point at which a cell loses its mating competence and commits to the cell cycle is called the “Start” point (8,9). It has been confirmed that Start is accurately predicted by the nuclear Whi5 concentration and is independent of cell size, cell type, and G1 duration (2).
Irreversible Transitions, Bistability and Checkpoint Controls in the Eukaryotic Cell Cycle: A Systems-Level Understanding
2013, Handbook of Systems BiologyIrreversible Transitions, Bistability and Checkpoint Controls in the Eukaryotic Cell Cycle: A Systems-Level Understanding. A Systems-Level Understanding.
2012, Handbook of Systems Biology: Concepts and InsightsAutomatic synchronisation of the cell cycle in budding yeast through closed-loop feedback control
2021, Nature Communications