Genetics of autoimmune disease
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Cited by (44)
Identification of novel susceptibility genes associated with seven autoimmune disorders using whole genome molecular interaction networks
2019, Journal of AutoimmunityCitation Excerpt :It has long been recognized that environmental influences and genetic factors play an important role in disease risk [13,14]. Interestingly, AuD have significantly higher inherited predisposition and can co-occur within families and even within individual patients, bolstering the hypothesis that clinically distinct AuD may share common genetic risk loci [11,15–18]. In support of this, genetic associations have been observed in PTPN2 and PTPN22 genes encoding protein tyrosine phosphatase, non-receptor type 2 and 22, respectively, with Crohn's disease (CD) [19], rheumatoid arthritis (RA) [20,21], systemic lupus erythematosus (SLE) [22], and type-1 diabetes (T1D) [23]; IL2 and IL21 genes encoding interleukin2 and interleukin 21, respectively, with celiac disease (CeD) [24,25], multiple sclerosis (MS) [26], T1D [23], and RA [20,27]; IFIH1 gene encoding the interferon induced with helicase C domain 1 with SLE [28] and T1D [29,30]; IL12A gene encoding interleukin 12A with MS, T1D [31], and CeD [31]; and SH2B3 gene encoding SH2B adaptor protein 3 with CeD [32] and T1D [33].
Type I interferons in Sjögren's syndrome
2013, Autoimmunity ReviewsCitation Excerpt :Genetic predisposition to Sjögren's syndrome was supported by the evidence of familial aggregation, animal models and candidate gene association studies [51]. The major histocompatibility complex (MHC) region is the most susceptible loci for onsets of autoimmune diseases [52–54]. A recent large scale meta analysis world wide of HLA and Sjögren's syndrome susceptibility further stressed the significant size effect HLA exhibited in the development of pSjS [55].
Genes and Sjögren's Syndrome
2008, Rheumatic Disease Clinics of North AmericaCitation Excerpt :The most well-characterized genes in the MHC region are the subset that encodes cell-surface antigen-presenting proteins. These genes, referred to as HLA genes, are well-documented risk factors for the development of autoimmune disorders.50,51 As with most autoimmune diseases, associations of HLA loci (mostly class II genes) have been described and vary in different ethnic groups with SS.1
Mechanisms underlying type I diabetes
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