Genetics of autoimmune disease

https://doi.org/10.1016/0952-7915(95)80049-2Get rights and content

Abstract

In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.

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