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doi:10.1016/0923-0467(96)80021-2 
Observer-based non-linear control of a fed-batch autoinductive fermentation process
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D. R. Lewina, *, B. Tartakovskya, B. E. Dainsona and M. Sheintucha
Received 8 October 1994;
Abstract
Optimal regulatory control of an autoinductive recombinant culture in a fed-batch reactor is considered. End point optimization results in a three-stage process: biomass growth, inducer synthesis and product synthesis. It is shown that in the last stage the substrate concentration should be maintained constant. This is achieved using an input-output linearizing controller accompanied by a novel non-linear state observer for the estimation of unmeasured state variables on the basis of on-line off-gas carbon dioxide concentration measurements. Experimental runs of luminous recombinant E. coli strain in a laboratory fermenter demonstrate the rapid convergence of the observer estimates as well as the effectiveness and robustness of the overall control system.
Author Keywords: Non-linear control; Fed batch autoinductive fermentation process; Optimal regulatory control
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