Chapter 10. Biology
XAFS of silver(I) metallothionein

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Abstract

Silver K-edge XAFS has been measured on Ag17-MT formed by adding Ag(I) to Zn7-MT at pH 7. The nearest neighbor bond length and coordination number are determined by curve-fitting using theoretical scattering amplitude and phase. It is found that the silver atom is coordinated with two sulfurs at 2.43 ± 0.024 Å and one Ag at 2.91 ± 0.05 Å. The results are compared to those of Zn7-MT, Cd7-MT, Hg7-MT and Hg18-MT. The generality of the coordination geometry of AgS clusters in various metallothioneins is noted.

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Cited by (4)

  • Studies of metal binding reactions in metallothioneins by spectroscopic, molecular biology, and molecular modeling techniques

    2002, Coordination Chemistry Reviews
    Citation Excerpt :

    EXAFS studies have provided bond lengths and coordination numbers for Zn7–MT, Cu12MT, Ag12MT, Hg17MT, Hg18MT, and Cd7–MT [14,37–40]. Interestingly, while the EXAFS data for the Zn7MT2A could be analyzed with extremely low standard errors, indicating a very similar set of bond lengths and coordination numbers, the data for the Cd7–MT2A protein showed much greater variation, indicating perhaps that there was more variability in the bond lengths and angles for the seven Cd(II) atoms [37–40]. The molecular modeling also suggests this [27].

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